Nobel in Hypoxia-inducible factor sparks studies in the same direction. Here is some essential study needed to understand the Hypoxia Nobel research.
Adapting to varying oxygen levels is one of the key evolutionary adaptations for most life forms on Earth and we too have adapted to that change. Each cell in the human body necessitates oxygen for its usual purpose. Both the environment and the physiological position of the body governs how much oxygen is available to cells. For example, in higher altitudes, oxygen availability decreases. This is especially important for mountain climbers and other frequent high altitude travelers, who must adapt to altitude in order to help their body increase the oxygen-carrying capacity in the blood. This process is essential to avoid mountain sickness and other altitude-associated health issues such as pulmonary and cerebral diseases and others that can be caused by oxygen level fluctuations in cells.
Many diseases such as fatty liver disease, metabolic and cardiovascular diseases are also associated with increased levels of HIF protein in various tissues which are governed by the oxygen levels in a cell. Animal studies have supported the strategy of removing HIF from specific tissues and the therapeutic value of targeting HIF in metabolic diseases.
As oxygen is involved in all cellular processes, the discovery of the mechanisms which enable the cells to detect the changes and rapidly respond to changes in oxygen levels has helped in revolutionizing biomedical research and helped to identify novel targets for various diseases treatments.
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