According to Australian researchers, a finding of the immune system’s reactions to malaria infection may pave way for improved lupus, HIV and hepatitis treatments.
Using lab models, the research group displayed how the intense inflammatory signals as a result of malaria infections start up the molecules which stimulate the generation of greatly potent antibodies to combat the illness.
Dr. Hansen, along with her team, spent the last couple of years discovering the response of the host immune system to malarial infections. It was previously assumed that the parasite’s capability to dodge immune identification was a vital characteristic in our weak ability to combat such infection.
Dr. Hansen, however, states how this is only a part of the whole story. She said how it is widely known that a person must continuously be subjected to malaria over many years to generate protective immunity. Through this process, the individuals are often sick and also spreading the illness.
She stated that the team intended to find out why the malarial infection was different from the other ailments, where immunity is guaranteed by only a single exposure to the disease.
Dr. Hansen that in their prior papers, the showed that the inflammatory signals triggered the molecules which arrested the helper T cells’ generation, implying that the B cells failed to get the required instructions for the generation of antibodies.
She said that when they began the research, they predicted seeing the inflammation having adverse impacts on the B cells. However, they discovered the very opposite. The inflammatory signals were seen to boost the quality of the produced antibodies, by moving B cells to a training ground where they went through a procedure to establish themselves as expert predators.
Tags : combat , illness, pave the way, Malaria discovery, treatments, HIV, lupus, immune system’s ,